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Practical Process Research and Development, by Neal G. Anderson
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This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students.
- Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules"
- Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more
- Includes over 100 tips for rapid process development
- Presents guidelines for implementing and troubleshooting processes
- Sales Rank: #1260821 in Books
- Brand: Neal G Anderson
- Published on: 2000-04-03
- Ingredients: Example Ingredients
- Original language: English
- Number of items: 1
- Dimensions: 9.21" h x .88" w x 6.14" l, 1.35 pounds
- Binding: Hardcover
- 354 pages
- Practical Process Research and Development
Review
"... A must reference on every process chemists (both the novice and the experienced practitioner) desk. This will be required reading by all new chemists, engineers and analysts in my department." --Sean T. Nugent, Searle Research and Development "Practical Process Research & Development is just that, practical... Especially enjoyable are author Neal G. Anderson's pithy 'tips'... Fun chemistry throughout." --CHEMICAL INNOVATION. June 2000 "The new volume by Dr. Anderson ranks with the very best on the subject covering almost all aspects of process research and development and scale up in an informative and readable manner. ...the many "Tips" given throughout the book are practical and informative and should be mandatory reading for all synthetic organic chemists, including those in research and discovery. ...could well become a standard text on the subject. Indeed, it is my recommendation that Process Chemistry departments throughout the industry buy two copies, one for themselves and one to help educate their colleagues in research/discovery. Many of the topics covered and the tips given in the book could also be of great use to anyone organizing organic chemistry practical courses for students. Perhaps the highest praise one can give this book is to say that Foreword by Barry Sharpless raises very high expectations and the book meets and at times exceed those expectations." --ORGANIC PROCESS RESEARCH AND DEVELOPMENT, Vol.4, No.5, 2000 "Following enthusiastic Forwards by Barry Sharpless and Jerry Moniot, each chapter of the book addresses commonly encountered aspects of large-scale synthesis. Drawing extensively from literature case studies for illustration, Anderson also sprinkles useful tips throughout the text, while his use of lists, tables, and charts aids in reinforcing key concepts. The text readily succeeds as a highly practical tour throughout the considerations of chemical scale-up. Newly minted chemists will find this a valuable introductory text, while veteran researchers will also glean much from Anderson's extensive experience. The book can easily be recommended as a reading for a graduate organic synthesis course. Medicinal chemists may find this trove of practical synthetic know-how quite useful in their drug discovery programs. Certainly all readers will better appreciate the challenges faced by process chemists in bringing a compound through development and commercialization." --Christopher R. Schmid, Senior Research Scientist, Lilly Research Laboratories, Eli Lilly and Company, JOURNAL OF MEDICINAL CHEMISTRY, 2001, Vol. 44, No.7 "In summary, we believe that every newcomer to the exciting field of process research and development should read this book, but also experienced process chemists and even academics will find it very useful and stimulating. As the language of stock analysts and brokers is very popular today, we recommend Practical Process Research and Development, by Neal G. Anderson, as a "strong buy" because this investment will pay off very quickly." --ANGEWANDTE CHEMIE, 2001, 40, No. 7. "...Filled with valuable insights and personal experience.... Dr. Anderson's book is indeed the best text on process development available to organic chemists. I have bought several for my group." --ADVANCED SYNTHESIS AND CATALYSIS, 2001, Oljan Repic, Director of Process R&D, Novartis Institute for Biomedical Research
From the Back Cover
Bringing a compound to market quickly and profitably requires efficient and
cost-effective processes for preparing large amounts of the target compound
and intermediates. The key to rapid and successful process development is avoiding scale-up problems. However, an understanding of scale-up issues is rarely
taught in academia and may take years of industrial experience to acquire.
Practical Process Research & Development teaches how to anticipate and
avoid these problems when processes are being scaled up from the research lab or
pilot plant. The approach is pragmatic, with a minimum of theory and over
100 practical scale-up tips. Many tables and detailed reaction schemes
allow the reader to identify critical processing steps quickly. This
practical guide is essential reading for chemists and chemical engineers
involved in industrial process research and/or process development and for
anyone seeking a clearer understanding of how and why process R&D is conducted in the pharmaceutical and fine chemicals industries.
KEY FEATURES
· Provides insights into generating rugged, practical, cost-effective
processes for the chemical preparation of "small molecules"
· Breaks down process optimization into route, reagent, and solvent
selection, development of reaction conditions, workup, crystallizations, and more
· Describes how to anticipate and avoid difficulties in scaling up reactions
· Discusses guidelines for the timely development of processes
· Illuminates principles with examples from the recent literature
· Includes over 100 tips for rapid process development
· Presents guidelines for implementing and troubleshooting processes
· Written by an author with over 22 years experience in process R&D in
the pharmaceutical industry
"... A must reference on every process chemists (both the novice and the experienced practitioner) desk. This will be required reading by all new chemists, engineers and analysts in my department."
--Sean T. Nugent, Searle Research & Development
About the Author
Neal G. Anderson, Ph.D., has worked for over 20 years in chemical process R&D in the pharmaceutical industry. He earned a B.S. degree from the University of Illinois and a Ph.D. in medicinal chemistry from the University of Michigan and completed post-doctoral studies at McNeil Laboratories. With almost 18 years in process R&D at Bristol-Myers Squibb Co. in New Brunswick, New Jersey, Dr. Anderson has extensive hands-on experience in the laboratory, pilot plant, and manufacturing facilities. He has made key contributions to processes for the manufacture of four major drug substances, including captopril, and has participated in 12 manufacturing start-ups and successfully introduced many processes to pilot plants. He received the Bristol-Myers Squibb President's Award and spot awards, and his final position was Principal Scientist.In 1997, Dr. Anderson established Process Solutions L.L.C., a consulting firm offering practical guidance on developing and implementing processes for bulk pharmaceuticals and fine chemicals. As part of these consulting services, he presents courses on selected aspects of practical process R&D.
Most helpful customer reviews
0 of 0 people found the following review helpful.
Five Stars
By kwangdo choi
Very GOOD!
0 of 0 people found the following review helpful.
For industrial R&D chemists
By Hongyi Wang
Imagine you have many "old-timers" giving out practical tips each from years of experience. That is not often happening. This book does exactly that.
It addresses process R&D in pharmaceutical and / or fine chemicals industry, taking one from laboratory bench to pilot or production scale. The differences and difficulties in scale-up were clearly demonstrated and the solutions provided. It educates and helps a R&D chemist or process chemist to ANTICIPATE, AVOID and OVERCOME the potential problems in process development and scale-up, at the START or EARLY stage of the project. Supported by many examples, the best practices and solutions are presented at the detailed technical level: routes, reagents, solvents, water, running and optimizing reactions, workup, chiral synthesis, etc.
The author highlighted a lot of key advice in "boxes" and allows a quick one-hour read of the best points.
0 of 0 people found the following review helpful.
The Editorial reviews say it all
By anon
I read this book cover to cover, come back to it many times. No other process chemistry book teaches better than this one. Highly recommended.
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